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ニュース&トピックス

第74回 日本癌学会学術総会にて学術発表

2015年9月4日

下記の要項にて学術発表を行います。


開催期間 2015年10月6日(木)〜10月10日(土)
10月10日(土)にポスター発表を行います。
会場 名古屋国際会議場
演題 重炭酸リンゲル液を用いたアテロコラーゲンの核酸DDS効果の向上
(演題番号:P-3370)
著者
(所属)
池田薫子、松永未知男、藤本一朗
(株式会社高研・研究所)
要旨 Atelocollagen (AC) is recognized as an excellent vehicle for delivering nucleic acid-based drugs (siRNA, miRNA, etc.) in various cancer models. AC is obtained by protease treatment of type I collagen, and has been known as a highly biocompatible and low immunogenic biomaterial for over three decades. Here, we introduce a new discovery: bicarbonate Ringer’s solution (BRS), which has been used for blood replacement during surgeries, enhances drug delivery efficiency. We found that a buffer action of BRS to siRNA/AC complexes reduced the time for fibril formation and increased the amount of siRNA retention in the complexes. To investigate the drug delivery efficiency of siRNA/AC complexes in BRS in vivo, we locally administered it to a subcutaneous mouse xenograft tumor model and demonstrated that it improved the RNA interfering effect of the siRNA. These results suggested that the improvement of the drug delivery efficiency of AC by BRS might have been due to the longer retention of siRNA during the experiment. Since both AC and BRS are biologically safe materials, our findings may lead to increased options for various cancer treatments.


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